ABSTRACT
Resumen: La necrosis grasa subcutánea es una paniculitis poco frecuente, autorresolutiva, que afecta generalmente neonatos de término en las primeras semanas de vida. Se han identificado ciertos factores de riesgo para su desarrollo como asfixia perinatal, hipotermia y aspiración de meconio. Sus complicaciones son infrecuentes, dentro de éstas se destaca la hipercalcemia por su gravedad. Se presenta el caso de un recién nacido que presentó necrosis grasa subcutánea. El diagnóstico se realizó en base a la clínica y el estudio histopatológico. El paciente evolucionó favorablemente con regresión de las lesiones sin complicaciones.
Summary: Subcutaneous fat necrosis is a rare, self-limiting panniculitis, which usually affects full term infants in the first weeks of life. There are several risk factors for its development such as perinatal asphyxia, hypothermia and meconium aspiration. Its complications are unusual, hypercalcemia being the most severe one among all. The study reports the case of a full term new born that presented subcutaneous fat necrosis. The diagnosis was based on clinical findings and histopathological study. The patient improved with regression of lesions, without complications.
Subject(s)
Humans , Male , Subcutaneous Fat , Fat Necrosis/diagnosis , Fat Necrosis/complications , HypercalcemiaABSTRACT
Newborn fat necrosis is an unfrequent disease that compromises the adipose tissue and develops during the first weeks of life. It is characterized by reddish-purple nodules and/or plaques with a hard elastic consistency, isolated or múltiple, localized at the back, shoulders, buttocks, arms, thighs and chin. They evolve spontaneously to regression and unfrequently develop complications, being hypercalcemia the most observed. The pathogenesis of newborn fat necrosis is unknown, although certain risk factors for its development have been identified. Case-report: A 36 weeks preterm male newborn with a clinical picture compatible with fat necrosis. The diagnosis was made according to the clinical findings and his perinatal history, confirming it with pathology. The patient evolution was complete improvement and regression of the lesions, without complications.
La necrosis grasa del recién nacido (NGRN) es una rara enfermedad que afecta al tejido adiposo y que se desarrolla durante las primeras semanas de vida. Se caracteriza por nodulos y/o placas eritemato-violáceas, de consistencia duro-elástica, únicas o múltiples, en dorso, hombros, glúteos, brazos, muslos y mejillas, que evolucionan espontáneamente hacia la regresión. Si bien pueden desarrollarse complicaciones, éstas son infrecuentes, siendo la más importante la hipercalcemia. La patogenia de la NGRN es desconocida, aunque se han identificado factores predisponentes para su desarrollo. Presentamos el caso de un recién nacido de pretérmino de 36 semanas, sexo masculino, que presentó un cuadro clínico compatible con NGRN. El diagnóstico se sospechó en base a la clínica, a los antecedentes perinatales y se confirmó con el estudio histopatológico. El paciente evolucionó satisfactoriamente con regresión de las lesiones y sin presentar complicaciones hasta la fecha.
Subject(s)
Humans , Male , Infant, Newborn , Hypercalcemia/etiology , Fat Necrosis/complications , Fat Necrosis/diagnosis , Biopsy , UltrasonographyABSTRACT
Subcutaneous fat necrosis of the newborn [SCFN] is an unusual disorder which occurs in term or post-term newborns due to perinatal stress. SCFN appears by firm nodules over the trunk, arm, buttock, thigh and cheeks in the first several weeks of life. Prevalence of SCFN is unknown. Race and sex do not play a role in this condition Hypocalcaemia and rarely hypercalcaemia are considered as major causes of morbidity and mortality in cases of SCFN. We report a case of SCFN in a two month male infant complicated with hypercalcemia and hyperuricemia
Subject(s)
Humans , Male , Subcutaneous Fat , Hypercalcemia , Fat Necrosis/complications , Hyperuricemia , InfantABSTRACT
Subcutaneous fat necrosis of the newborn (SCFN) is an uncommon disorder in full term infants who have a perinatal condition. The authors reported seven cases of subcutaneous fat necrosis of the newborn at Queen Sirikit National Institute of Child Health from 2002 to 2005. All cases were term babies with four male cases, and three female cases. Five cases (70%) had perinatal asphyxia. The mean age of onset was 14 days (range 3-42 days). The locations of SCFN were back (3 cases), shoulder (2cases), arm (2 cases), buttock (1 case), and neck (1 case). Skin biopsy was performed in three cases and was compatible with subcutaneous fat necrosis. The treatment was supportive with close monitoring of serum calcium. Hypercalcemia was seen in five cases (70%) and three cases were treated with oral prednisolone. Cutaneous lesions of all cases resolved without sequelae. In conclusion, infants with subcutaneous fat necrosis should have serial serum calcium determinations and should be observed closely for signs and symptoms of hypercalcemia such as irritability, anorexia, constipation, and failure to thrive.
Subject(s)
Fat Necrosis/complications , Female , Humans , Hypercalcemia/diagnosis , Infant, Newborn , MaleABSTRACT
En 246 pancreatitis agudas hemos registrado 27 complicaciones sépticas pancreáticas. Fueron clasificadas en 3 grupos: I- necrosis pancreáticas supuradas, 9 casos; II-necrosis y abscesos de páncreas, 12 casos y III-seudoquistes infectados, 6 casos. En la etapa inicial de la enfermedad -preoperatoria- la ascitis enzimática no se correlacionó con una mayor mortalidad (para X2p=0,3), pero se comprobó un incremento de la misma en relación al número de fallas orgánicas. En el postoperatorio inmediato la desaparición de las fallas orgánicas constituyó un signo de buen pronóstico. Los pacientes operados precozmente, generalmente por error diagnóstico, presentaron una mayor mortalidad que los operados tardíamente (para X2p<0,001). La mortalidad fue del 22,2 por ciento, 33,3 por ciento y 16,6 por ciento para cada grupo respectivamente. Los cultivos de las necrosis y colecciones infectadas evidenciaron un predominio de enterobacterias que orientan a una traslocación bacteriana intestinal. Hemos observado una persistencia del estado séptico en el postoperatorio de los pacientes que curaron, a pesar de no existir evidencias de enfermedad pancreática en la tomografía computada